How does PDT Work?
The principle is simple. A sensitizer is put into the body and, if it is designed properly, it goes to bad organisms like cancer bacteria and viruses. When it is activated by a light of the right wavelength, it converts the oxygen near it to a very toxic form of oxygen which kills the bad organisms.
Of course this is a very simplified explanation and there is a vast amount of technology involved in making this work properly. We provide papers throughout the site for the technically minded, so I won't discuss further details here.
Why Do We Claim to be the Only 4th Generation Provider?
Like any technology, PDT has been improving with time as new advancements are made in the sensitizers and lasers.
The first generation sensitizers, photofrin and ALA, had big problems which they could never overcome. They accumulate in the skin heavily, are activated by UV, and their activating wavelength is absorbed heavily by blood. Consequently patients had to have ZERO sunlight for a full month, they could not be treated through the skin so surgery was necessary to get the light in, and most importantly they could not kill more than 3mm of tumor at a time. In short, they were pretty worthless but even so they got the ball rolling to stimulate further advancements.
Second generation sensitizers, notably the chlorin and chlorin derivative molecules solved some of the problems, but they had poor selectivity and a number of other limitations, including an improved but still unacceptable penetration depth.
There are in my opinion only two third generation sensitizers, our molecule and a similar molecule which has low selectivity issues. It also is not convenient to "functionalize" so it does not lend itself to targeting specific tissues so it can not be used for most of our applications.
There is only one fourth generation sensitizer in existence because no other provider has created a perfect nanomolecule shell for their sensitizer. The nanomolecule is critical for targetting cancer well enough to treat deep into the body.
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